Subjects
Abstract
Objective
To assess the impact of chlorhexidine gluconate (CHG) bathing on skin bacterial burden in neonates.
#7def43 color RGB value is (125,239,67). #7def43 hex color red value is 125, green value is 239 and the blue value of its RGB is 67.
Study design
In this prospective observational study, arm and groin skin bacterial growth was measured in 40 CHG-exposed and nonexposed neonates admitted to the NICU. Exposed neonates received 2% CHG baths per protocol for central line-associated bloodstream infection (CLABSI) prevention or Staphylococcus aureus decolonization.
Results
Forty neonates were enrolled, 18 of whom were CHG-exposed. Mean baseline Gram-positive (GP) bacterial burden was 2.19 log CFU/ml on the arm and 1.81 log CFU/ml on the groin. Bacterial burden decreased after the first bath, but returned to baseline by 72 h. Residual skin CHG concentration declined over time, with a corresponding increase in GP bacterial burden.
Conclusions
CHG bathing reduces skin bacterial burden, but burden returns to baseline after 72 h. Twice weekly CHG bathing may be inadequate to suppress skin bacterial growth in hospitalized neonates.
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Acknowledgements
The authors wish to thank the study’s participants and their families, as well as Annie Voskertchian and Anne King for their study support, and Dr. Mary K. Hayden and her colleagues at Rush University for sharing their colorimetric assay protocol.
Funding
This study was supported by an investigator-initiated research grant from Sage Products, LLC, and NIH Training Grant Award T32 HL 125239-1 (JJ).
Author information
Correspondence to Julia Johnson.
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The authors declare that they have no conflict of interest.
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